Acsl4 degradation

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August undefined, 2024

WebApr 12, 2024 · Our results revealed that lower level of ferroptosis-related proteins GPX4 in cartilage layer, but the level of ACSL4 and P53 increase in that of condyle. Injection of ferroptosis inhibitor liproxstatin-1 (Lip-1) effectively decrease ACSL4, P53 and … WebJun 13, 2024 · E Acsl4 mRNA expression levels in Acsl4 shRNA-mediated knockdown PL1 cells and Acsl4-overexpression PG7 cells were determined by qPCR. Data indicated as mean ± S.D. ( n = 3 experiments).

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ACSL4 - Wikipedia

WebOct 15, 2024 · ACSL4 can exert opposing roles acting as a tumor suppressor or as an oncogene depending on the specific cancer type and tissue environment. Moreover, ACSL4 behaves as a crucial regulator in ferroptosis that is defined as a cell death process caused by iron-dependent peroxidation of lipids. WebApr 14, 2024 · As expected, we found that CYP1B1 overexpression increased poly-ubiquitin chain linked-ACSL4 (Fig. 2H ), whereas CYP1B1 knockdown reduced the … WebMar 14, 2024 · The activated HSPs either support the refolding of misfolded proteins or target them for proteasomal degradation . ... ACSL4 and LPCAT3 enzymes are required for the initiation of ferroptosis. ACSL4 catalyzes the acylation of PUFAs, which are then inserted into membrane PLs via the action of LPCAT enzymes. PUFA-containing membrane PLs … human 4rm3

Downregulation of hepatic ACSL4 expression in hepatic cells by …

Identification of p115 as a novel ACSL4 interacting protein and its ...

WebOct 30, 2024 · ACSL4 preferentially esterifies polyunsaturated fatty acids such as arachidonic acid. • AA induces ACSL4 degradation via the ubiquitin-proteasome … WebThe ACSL4 gene is located on the X-chromosome, with its specific location being Xq22.3-q23. The gene contains 17 exons. [7] ASCL4 encodes a 74.4 kDa protein, FACL4, which … human ab serum gibcoWebArachidonic acid downregulates acyl-CoA synthetase 4 expression by promoting its ubiquitination and proteasomal degradation [S] ACSL4 is a member of the long-chain acyl-CoA synthetase (ACSL) family with a marked preference for … human 800 number

"WebConsistent with free AA suppressing ACSL4 levels by promoting its ubiquitination and proteasomal degradation, 32 we found that ACSL4 was decreased in N27 cells after … " - Acsl4 degradation

Acsl4 degradation

Liproxstatin-1 alleviates cartilage degradation by inhibiting ...

WebApr 14, 2024 · Collectively, these data demonstrated that 20-HETE, a metabolite of AA, enhances ACSL4 degradation by activating the PKC signaling pathway and inducing the expression of E3 ubiquitin ligase FBXO10. WebMay 27, 2024 · Pretreatment of these cells with ferrostatin-1 (Fer-1), an arylalkylamine that was identified as one of the first chemical inhibitors of ferroptosis, which has been suggested to act by preventing oxidative damage to membrane lipids , blocked ACSL4 degradation completely (Fig. 2a). These data validate the integral role of ACSL4 in ferroptosis ...

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WebArachidonic acid induces ACSL4 protein degradation 1659 ACSL4 mRNA half-life determination g protein were incubated with anti-ACSL4 antibody or a control antibody (rabbit IgG) overnight at... WebIt has been reported that in hepatic cells and primary cortical neurons, ACSL4 is degraded mainly through the proteasome pathway [34,35]. However, as previously hypothesized, the lysosome...

WebFeb 12, 2024 · ACSL4 acyl-CoA synthetase long chain family member 4 Gene ID: 2182, updated on 12-Feb-2024 Gene type: protein coding Also known as: ACS4; FACL4; LACS4; MRX63; MRX68; XLID63 See all available tests in GTR for this gene Go to complete Gene record for ACSL4 Go to Variation Viewer for ACSL4 variants Summary WebMar 21, 2024 · ACSL4 (Acyl-CoA Synthetase Long Chain Family Member 4) is a Protein Coding gene. Diseases associated with ACSL4 include Intellectual Developmental Disorder, X-Linked 63 and Stroke, Ischemic.Among its related pathways are Fatty acid metabolism and Integration of energy metabolism.Gene Ontology (GO) annotations related to this …

WebFACL proteins are important for synthesis of cellular lipids and for β-oxidation degradation. Specifically, ACSL proteins catalyze the activation of long-chain fatty acids to acyl-CoAs, which can be metabolized to form CO2, triacylglycerol (TAG), phospholipids (PL) and cholesteryl esters (CE). WebAug 8, 2024 · The degradation of Nrf2 is mediated by Keap1-dependent ubiquitin-proteasome pathway under quiescent conditions ... ACSL4 forms acyl-CoAs by catalyzing fatty acids and affects the lipid composition . Activation of ACSL4 has been indicated to promote ferroptosis [47, 57].

WebMar 15, 2024 · Hepcidin acts by inducing endocytosis and subsequent degradation of FPN. The Tet1-RNF217-FPN axis, a newly recognized pathway, ... (ACSL4) and lysophosphatidylcholine acyltransferase 3 (LPCAT3) are important enzymes responsible for the biosynthesis and remodeling of PUFA-phosphatidylethanolamines .

WebAug 27, 2024 · As shown in Fig. 2A, the expression of ACSL4 mRNA was reduced >90% in the adrenal (P < 0.001), Leydig cells (P < 0.001), and ovary (P < 0.01) of KO mice … human ab serum gemini bioproductsWebNov 24, 2024 · Peroxisome-dependent and independent initiation of ferroptotic pathways. The peroxidation of PUFAs by ALOXs or POR to produce LOOH is an important step in promoting ferroptosis. The synthesis of ... human \u0026 beingsWebHepatic ACSL4 was significantly decreased in both of our NASH models and is also decreased by high-fat diet feeding in mice (36). Interestingly, free arachidonic acid causes ACSL4 to be... human ab serum hp1022WebMar 19, 2024 · Identification of p115 as a novel ACSL4 interacting protein and its role in regulating ACSL4 degradation. Journal of Proteomics, Volume 229, 2024, Article 103926. Show abstract. Long-chain acyl-CoA synthetase 4 (ACSL4) is an ACSL family member that exhibits unique substrate preference for arachidonic acid. ACSL4 has a functional role in … human ab serum sigma h4522Web图2c-d：acsl4低表达的肺腺癌患者的无进展生存期（pfs）和总生存期（os）更差。作者对tcga数据库中524例肺腺癌患者进行通路富集分析，值得注意的是，gsea和go富集分析 … human ab serum gemini bioWebOverexpression of ACSL4 results in a higher rate of arachidonoyl-CoA synthesis, increased 20:4 incorporation into phosphatidylethanolamine, phosphatidylinositol, and triacylglycerol, and reduced cellular levels of unesterified 20:4. Additionally, ACSL4 regulates PGE 2 release from human smooth muscle cells. human ab serum vs fbsWebIt has been reported that in hepatic cells and primary cortical neurons, ACSL4 is degraded mainly through the proteasome pathway [34,35]. However, as previously hypothesized, … human abacus