Gene that codes for the urate transporter 1

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August undefined, 2024

WebSep 11, 2024 · The highest score was obtained for the product of the PA3228 gene that encodes a putative ABC transporter (code access UniprotKB Q9HZ12). Table 1 shows … WebThe protein encoded by this gene is a urate transporter and urate-anion exchanger which regulates the level of urate in the blood. This protein is an integral membrane protein …

Molecular Background of Urate Transporter Genes in

WebApr 28, 2009 · The cDNA, which they called URAT1 for 'urate transporter-1,' corresponds to a gene of 2,642 basepairs encoding a protein of 555 amino acids that is 42% identical to OAT4 (SLC22A11; 607097 ). The hydropathy plot predicts 12 membrane-spanning domains in URAT1, which are similar to those in members of the OAT family. WebSep 15, 2024 · Urate transporter 1 (URAT1) and glucose transporter 9 (GLUT9) are important transporters involved in urate reabsorption (Fig. 1) (Benn et al., 2024; So and Thorens, 2010; Vadakedath and Kandi, 2024; Xu et al., 2024), and the research on URAT1 is more extensive.In 2002, Enomoto et al. first searched for the URAT1 gene. build fm antennas for receivers

Human Gene SLC17A3 (ENST00000397060.8) from GENCODE V43

WebSep 15, 2024 · Urate transporter 1 (URAT1) is a major protein involved in uric acid reabsorption (about 90%). Therefore, URAT1 inhibitors are considered to be a highly … WebAnother urate transporter gene, glucose transporter 9 (GLUT9/SLC2A9), has also been identified by genome-wide association studies (GWAS) of SUA (17–19). So far, we have demonstrated that loss-of-function mutations in two urate transporter genes, URAT1 and GLUT9 , cause renal hypouricemia type 1 [Mendelian Inheritance in Man (MIM) 220150] … WebA genetic defect in urate transporter 1 (URAT1) is the major cause of renal hypouricemia (RHUC). Although RHUC is detected using a serum uric acid (UA) concentration <2.0 mg/dL, the relationship ... build fm black

Genetic Links to High Uric Acid and Gout

Personalized Medicine of Urate-Lowering Therapy for Gout

WebDec 2, 2013 · lizes the apical urate transporter network (1, 10, 27, 40). However, the aforementioned genome-wide association studies have shown that genetic variants of solute carrier family 2, member 9 (SLC2A9), are of major relevance for human urate homeostasis, whereby the minor alleles of the identiﬁed SNPs were associated with … WebURAT1. URAT1 is encoded by the SLC22A12 gene and has a typical OAT structure. 24 URAT1 is highly specific for urate. It mediates the exchange of urate for a variety of endogenous and drug anions known to affect renal uric acid transport. URAT1 can transport urate in either direction across the tubular cell membrane, depending on the relative ... croswell and adamsWebFor example, the urate transporter genes SLC2A9, ABCG2 and SLC22A12 modulate serum uric acid levels and gout risk. The net balance between renal urate absorption and secretion is a major determinant of serum uric acid concentration and loss-of-function mutations in SLC2A9 and SLC22A12 cause hereditary hypouricaemia due to reduced … build fm broadcast transmitter

"WebMar 28, 2024 · Of these 10 OAT family transporters, OAT3 and OAT4 help in reabsorption of UA from urine. SLC22A12 codes for a protein, urate transporter 1 (URAT1), which is a … " - Gene that codes for the urate transporter 1

Gene that codes for the urate transporter 1

WebNov 24, 2004 · We report the novel cloning and preliminary characterization of a human urate transporter (hURAT1) gene promoter. The transcription initiation site was … WebExpression of Urate transporter 1 (URAT1/SLC22A12) is restricted to the proximal tubules in the kidney, where it is responsible for the tubular reabsorption of urate. To elucidate the mechanism underlying its tissue-specific expression, the transcriptional regulation of the hURAT1 and mUrat1 genes was investigated.

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WebSep 4, 2012 · Urate secretion involves SLC22A6 and SLC22A8, which transport uric acid into the epithelial cell across the basolateral membrane, and URAT1, SLC22A13, … WebMar 27, 2024 · In a majority of patients, the defects are caused by loss-of-function mutations in the SLC22A12 gene that codes for the urate transporter URAT1 (RHUC1). Furthermore, another key player glucose transporter 9 (GLUT9; RHUC2) in UA homeostasis proved to be central to urate reabsorption.

WebURAT1, a member of the OAT (organic anion transporter) family, is an anion-exchanging uptake transporter localized to the apical (brush border) membrane of renal proximal tubular cells [1, 2], where it mediates the re-absorption of uric acid from the proximal tubule, … WebThe SLC22A12 gene provides instructions for making a protein called urate transporter 1 (URAT1). This protein is found in the kidneys, specifically in structures called proximal …

WebMar 20, 2024 · The SLC17A3 gene encodes a sodium phosphate transporter (NPT4) which is expressed at the apical membrane of renal proximal tubule cells. The SLC17A1 gene … WebMar 28, 2024 · Probable Potential Role of Urate Transporter Genes in the Development of Metabolic Disorders. March 2024; Cureus 10(3):1-20; ... ABCG2 gene codes for ATP binding cassette (ABC) transpo rter.

WebSep 14, 1990 · Using the cDNA and selected genomic probes of rat urate oxidase, we have screened the human genomic library and isolated seven clones; one clone (clone 13) …

WebMar 29, 2024 · The protein encoded by this gene is a member of the organic anion transporter (OAT) family, and it acts as a urate transporter to regulate urate levels in blood. This protein is an integral membrane protein primarily found in epithelial cells of the proximal tubule of the kidney. An elevated level of serum urate, hyperuricemia, is … build fm bloodWebGenetic variation in the SLC2A9 gene is a new genetic risk factor for low fractional excretion of uric acid, hyperuricemia, and gout. Its gene product, GLUT9, was previously known as a type II glucose/fructose transporter but is now known to function as a high-capacity uric acid transporter that is expressed in kidney, liver, and several other tissues. croswell apartmentWebMar 20, 2024 · 3.1 Genetic and genomic approaches of hyperuricaemia and gout ... (ABCB1) gene is highly polymorphic and codes for the drug efflux pump MDR1, and as such is considered an important gene that ... Gray NK, Floyd J, Palmer CN, et al. SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate … build flynnWebUrate transporter 1 (URAT1) is a major urate transporter involved in renal uric acid reabsorption and excretion, making it an important anti-HUA drug target. To better … build fly rodWebJan 10, 2024 · The solute carrier family 6 member 4 (SLC6A4) gene, which spans from 17q11.1 toq12, encodes for the serotonin transporter (5HTT, SERT) [44,92,93]. The … croswell bowenWebLR1155 and LF2644 significantly elevated the fecal UA levels, increased the UA content and up-regulated gene expression of UA transporter, ATP-binding cassette subfamily G-2 (ABCG2), in colon and ... build foam fractionatorWeb16 rows · URAT1. URAT1 is encoded by the SLC22A12 gene and has a typical OAT structure. 24 URAT1 is highly ... build fnaf characters