Web25 sep. 2014 · Opioids. The second major class of painkillers are the opioids. These are a class of drugs related to morphine, the compound found in significant concentrations in the opium poppy. The opium poppy itself has been used for its natural painkilling properties for centuries, as the opium which can be extracted from it contains around 12% morphine. http://nida.nih.gov/research-topics/opioids
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