Nigericin function
WebbNigericin is a polyether ionophore; it is reported to have a very potent antibacterial, antifungal, antiviral, antimalarial and anticancer activity. 6–9 Nigericin is produced … WebbNational Center for Biotechnology Information
Nigericin function
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Webb21 juni 2010 · In contrast, the antibiotic valinomycin functions as a K +-carrier that specifically dissipates the ΔΨ in the presence K + ions . All tested proteins that featured CCCP-dependent changes in localization pattern were also sensitive to valinomycin, whereas dissipation of the ΔpH by nigericin had no influence (Fig. 4 and Fig. S6A). WebbNigericin sodium salt acts as a potassium ionophore. It probably activates NLRP3 through the intracellular potassium (K+) efflux across the membrane [1]. Whether the formation of non‑selective pannexin-1 pores also contributes to NLRP3 activation upon …
Webb29 jan. 2024 · Similar to cultures stimulated with LPS/ATP, OLT1177 inhibited IL-1β release in murine macrophages stimulated with LPS and nigericin (Fig. 1F), without affecting TNFα levels (Fig. 1G). Although LPS/ATP stimulation can result in lactate dehydrogenase (LDH) release as a measure of cell death, in the presence of OLT1177, … Webb11 jan. 2006 · The release of IL-1β in response to nigericin, a potassium ionophore, and ... The adaptor protein ASC is essential for inflammasome function 1,2, binding directly to caspase-1 (refs 3 ...
Webb1 mars 2024 · Whereas, in the class of molecular functions, “binding” was the more enrichment subclass, followed by “catalytic activity” and “molecular function regulator” (Fig. S4A). Between the GO analyses of down-regulated genes in the biological procedure, the most enrichment subclass was the “cellular process”. Webb2 juni 2024 · Neutrophils release neutrophil extracellular traps (NETs) which ensnare pathogens and have pathogenic functions in diverse diseases. We examined the …
WebbNigericin C40H68O11 CID 34230 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, …
Webb5 maj 2024 · Nigericin- or ATP-stimulated IL-1β release was significantly decreased in Atg7 M∆ neutrophils relative to Atg7 f/f neutrophils (Fig. 4a), even though the cells were … seconds from disaster pearl harborWebb3 feb. 2024 · LPS/Nigericin treatment resulted in poor visualization of cristae in PC3 and A549 cell lines, indicating reduced mitochondrial function (Figures 5M, N). Unlike in tumor cells, Nigericin and LPS/Nigericin produced better-defined cristae in fibroblast mitochondria compared to untreated controls, suggesting an increased mitochondrial … second sex characteristics of femaleWebbNigericin is a potent microbial toxin that acts as a potassium ionophore, inducing a net decrease in intracellular levels of potassium. This is critical for the oligomerization of the … puppetdb refreshes on each puppet runWebbNigericin is a microbial toxin derived from the Gram-positive bacteria Streptomyces hygroscopicus. It induces the release of IL-1β in response to the activation of the … seconds from disaster train wreckWebb5 apr. 2012 · Like nigericin, monensin treatment disrupts lysosomal function (27, 39). Immunoblotting with anti-LC3 antibody and quantitative analysis showed that the time-dependent increase in LC3-II following monensin treatment was not exacerbated by the presence of chloroquine, indicating that monensin also impaired autophagic flux in … secondshaadi com searchWebbIntracellular calibration of the fluorescence response of cytosolic pH indicators is typically performed using the K + /H + ionophore nigericin, which causes equilibration of … second set of macro keysWebb21 okt. 2024 · Herein, we report that the NLRP3:ASC speck is not required for nigericin-induced inflammasome activation but facilitates and maximizes IL-1β processing. … puppet debug with notify