WebThe novel molecule, designated NFATx, exhibits in its middle a region very similar to the Rel homology domain in NFATc and NFATp. The amino-terminal region of NFATx also shows significant similarities to corresponding sequences in NFATc and NFATp and contains three copies of a conspicuous 17-residue motif of unknown function. WebNov 16, 2000 · The Rel homology region (RHR) is known to be important both for dimerization of NF-κB/Rel subunits (Grimm and Baeuerle, 1993), as well as for interaction with many of these other proteins ...
The rel family of proteins - PubMed
WebNuclear factor of activated T cells (NFAT) and recombination signal binding protein (RBP) belong to the family of Rel homology region (RHR) transcription factors which regulate … WebAll these proteins share a highly conserved 300 aa Rel homology region (RHR), which is responsible for dimer-ization, DNA-binding and interaction with the inhibitory IκB proteins. chat trampoline
Transcription factor - Wikipedia
WebThe rel family of proteins can be defined as a group of proteins that share sequence homology over a 300 amino acid region termed the rel domain. The rel family comprises … WebMar 21, 2024 · The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. WebTranscription factors bind to either enhancer or promoter regions of DNA adjacent to the genes that they regulate. ... 4.1 Class: RHR (Rel homology region) 4.1.1 Family: Rel/ankyrin; NF-kappaB; 4.1.2 Family: ankyrin only; 4.1.3 Family: NFAT (Nuclear Factor of Activated T-cells) (NFATC1, NFATC2, NFATC3) 4.2 Class: STAT chat transparent background