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Rel homology region

WebThe novel molecule, designated NFATx, exhibits in its middle a region very similar to the Rel homology domain in NFATc and NFATp. The amino-terminal region of NFATx also shows significant similarities to corresponding sequences in NFATc and NFATp and contains three copies of a conspicuous 17-residue motif of unknown function. WebNov 16, 2000 · The Rel homology region (RHR) is known to be important both for dimerization of NF-κB/Rel subunits (Grimm and Baeuerle, 1993), as well as for interaction with many of these other proteins ...

The rel family of proteins - PubMed

WebNuclear factor of activated T cells (NFAT) and recombination signal binding protein (RBP) belong to the family of Rel homology region (RHR) transcription factors which regulate … WebAll these proteins share a highly conserved 300 aa Rel homology region (RHR), which is responsible for dimer-ization, DNA-binding and interaction with the inhibitory IκB proteins. chat trampoline https://telgren.com

Transcription factor - Wikipedia

WebThe rel family of proteins can be defined as a group of proteins that share sequence homology over a 300 amino acid region termed the rel domain. The rel family comprises … WebMar 21, 2024 · The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. WebTranscription factors bind to either enhancer or promoter regions of DNA adjacent to the genes that they regulate. ... 4.1 Class: RHR (Rel homology region) 4.1.1 Family: Rel/ankyrin; NF-kappaB; 4.1.2 Family: ankyrin only; 4.1.3 Family: NFAT (Nuclear Factor of Activated T-cells) (NFATC1, NFATC2, NFATC3) 4.2 Class: STAT chat transparent background

NFATx, a Novel Member of the Nuclear Factor of Activated T Cells …

Category:Evidence for a non-a-helical DNA-binding motif in the Rel homology region

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Rel homology region

A Similar DNA-binding Motif in NFAT Family Proteins and …

WebRel Homology Domain. 92,93 The RHD is also known as the DNA-binding domain (DBD) of NFAT proteins, which shows a structural similarity to the DBD of nuclear factor-κB (NF … WebAug 31, 2003 · The crystal structure of the NFAT1 Rel homology region (RHR) bound to a pseudo-palindromic DNA site reveals an asymmetric dimer interaction between the RHR-C …

Rel homology region

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WebThe Rel homology domain (RHD) is a protein domain found in a family of eukaryotic transcription factors, [2] including both NF-κB and NFAT, among others. Some of these transcription factors appear to form multi-protein DNA -bound complexes. [3] … WebFeb 24, 1995 · Within this region, there is a span of ∼300 amino acids that shows a low level of sequence identity with the Rel homology region (RHR) previously recognized in Rel …

WebDec 30, 2024 · Passionate about developing regional and global tech innovation ecosystems and champion of the Global Innovation … WebFeb 1, 1996 · The defining characteristic of Rel proteins is a stretch of roughly 300 amino acids called the Rel homology region (RHR) or Rel homology domain (RHD), within which …

WebJan 26, 1995 · The 2.3-A crystal structure of the transcription factor NK-kappa B p50 homodimer bound to a palindromic kappa B site reveals that the Rel homology region … WebMar 1, 1994 · Within the Rel homology region of NF-kappa B p50 (also known as KBF1), two amino acid residues were identified by photocrosslinking to adjacent bases in a beta-interferon regulatory element.

WebOct 19, 2024 · 10.3.1 Rel Homology Region (RHR) Structure. The first glimpse into the structural details of the NF-κB pathway was afforded by two separate X-ray crystallographic analyses of the NF-κB p50:p50 homodimer RHR in complex with κB DNA [20, 50].

WebFeb 1, 1994 · Europe PMC is an archive of life sciences journal literature. chat translator roblox scriptWebThe sequence of this region of NFATp shows a low degree of similarity to the Rel homology region. One specific short sequence in NFATp (RAHYETEG), located near the NH2 terminus of the DNA-binding domain, … chat transparente obsWebJun 22, 1999 · The Rel homology region of NFAT5 showed 41–45% identity with NFAT1–4 and 15–17% identity with p50 NF-κB in pairwise comparisons (Fig. 2 a and b), indicating … customize your own retro jordansWebFeb 1, 1994 · Within the Rel homology region of NF-kappa B p50 (also known as KBF1), two amino acid residues were identified by photocrosslinking to adjacent bases in a beta-interferon regulatory element. Secondary structure analysis suggests that the DNA-binding motif of the Rel homology region comprises a beta-turn-beta structure, in contrast to the … chat transfercustomize your own ring holderWebRel Homology Region (RHR) Class I p50 Class II p65 c-Rel ReIB C kB DNA N N N N C C p50 RHR p50 D256 N200 F213 p65 GGG5´ Y269 R56 R58 H66 Y59 p65 RHR C p52 A CD F E B NTD DimD LG 433 NTD DimD L 447 NTD DimD TADL 551 N NTD DimD TAD 619 Amino-terminal domain Dimerization domain C Linker L LZ NTD DimD L TAD 557 G Figure2. The … chat trapWebJun 6, 2003 · Using bioinformatics tools, we identified a Rel homology region (RHR) within CSL that was used as a guide to determine the minimal protein requirements for ternary complex formation. The RHR of CSL contains both the N- and C-terminal beta-sheet domains (RHR-n and RHR-c) of typical Rel transcription factors, as judged by circular dichroism … chat tra pc in rete