Siglec family
WebApr 26, 2024 · Because of their restricted cell type expression and roles as checkpoints in immune cell responses in human diseases such as cancer, asthma, allergy, … Siglecs (Sialic acid-binding immunoglobulin-type lectins) are cell surface proteins that bind sialic acid. They are found primarily on the surface of immune cells and are a subset of the I-type lectins. There are 14 different mammalian Siglecs, providing an array of different functions based on cell surface receptor-ligand … See more The first described candidate Siglec was Sialoadhesin (Siglec-1/CD169) a lectin-like adhesion protein on macrophages. Parallel studies by Ajit Varki and colleagues on the previously cloned CD22 (a B cell surface protein involved in See more The primary function of Siglecs is to bind glycans containing sialic acids. These receptor-glycan interactions can be used in cell adhesion, cell … See more Many pathologies have been linked to the spontaneous interactions between sialic acid and the immunosuppressive sialic acid-binding … See more Siglecs are Type I transmembrane proteins where the NH3 -terminus is in the extracellular space and the COO -terminus is See more This table briefly summarises the cellular distribution of each human/primate Siglec; the linkage specificity each has for sialic acid binding; the number of C2-Ig domains it contains; and … See more • Functional Glycomics Gateway, a collaboration between the Consortium for Functional Glycomics and Nature Publishing Group • I-type Lectins (Siglecs) Research conducted at Imperial College London providing another overview of I-type Lectins See more
Siglec family
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WebFeb 18, 2024 · Transcriptional expression of SIGLEC family members in ICGC and GEO databases. Expression levels of SIGLEC family genes in cancer and normal tissues based … WebIt is defined as an I-type lectin, since it contains 17 immunoglobulin (Ig) domains (one variable domain and 16 constant domains), and thus also belongs to the immunoglobulin …
WebNov 13, 2024 · Siglec-8, a CD33-related family member, is often found on human eosinophils, mast cells, and weakly on basophils . Although it can exist as two spliced … WebThe Siglec Family. The numbering of Human Siglecs follows the order of their discovery. The representatives murine Siglecs that are not homologous to the human ones are designed …
WebCD33 antigen or Siglec-3, is a member of the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. This Single-pass type I membrane protein contains 1 Ig-like C2-type (immunoglobulin-like) domain and 1 Ig-like V-type (immunoglobulin-like) domain. CD33/Siglec-3 induces apoptosis in acute myeloid leukemia (in vitro). WebA new siglec family member, siglec-10, is expressed in cells of the immune system and has signaling properties similar to CD33 Gena Whitney1, Shulin Wang1, Han Chang2, Ke-Yi …
WebThe K8 monoclonal antibody specifically recognizes Sialic acid-binding Ig-like lectin 9 (Siglec-9) which is also known as CD329. Siglec-9 ... B cells and T cells. Siglec-9 (CD329) …
WebAlexa Fluor™ 647-Labeled Human Siglec-3 / CD33 Protein, His TagStar Staining 400-682-2521 [email protected] 注册 登录 登录 注册 关注公众号 dynamics motionWebMulti-pass Tps FLAG Claudin Family Claudin 18.2 GPCRs CD20 proteins Proteins for Neuroscience Proteins for Neuroscience New Pre-formed Fibrils (PFFs) New Aneuro ... New Complement Components New CD39/CD73 proteins B7 families TNFSF proteins PD1 proteins TIGIT Siglec-15 proteins Integrin CD24&siglec-10 cry\u0027s companion crosswordWebJun 15, 2024 · Siglec 受体Siglec family. ... 所有 Siglecs 都是单通道 1 型整合膜蛋白，含有一个（或两个，在 Siglec-12 的情况下）独特且同源的 N 端 V 组 Ig 结构域的细胞外结构域，然后是可变数量的 C2 组 Ig 结构域，范围从唾液酸粘附素中的 16 到 CD33 中的 1。 dynamics mrssWebCD22, or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins. It is found on the surface of mature B cells and to a lesser extent on some … dynamics msxWebDec 20, 2001 · Using the Stanford G3 radiation hybrid panel we were able to localize the genomic sequence of siglec-10 within the cluster of genes on chromosome 19q13.3-4 … cry\\u0027s laughWebApr 13, 2024 · Many pathogens rarely cause invasive diseases during neonatal life. Bee et al. delineate an immunologic determinant of this phenomenon. During early life, developmental impairments in macrophage function (efferocytosis) alter neutrophil homeostasis to augment CD11b-dependent opsonophagocytosis. This results in increased protection … dynamics modelWebCreative Biolabs offers high-quality Rat Anti-Mouse Siglec-H Monoclonal Antibody (Clone 551) to boost neuroscience research. dynamics multiplexing